Early detection is crucial for timely intervention aimed at preventing and slowing the progression of neurocognitive disorder (NCD), a common and significant health problem among the aging population. Recent evidence has suggested that language-related functional magnetic resonance imaging (fMRI) may be a promising approach for detecting cognitive decline and early NCD. In this paper, we proposed a novel, naturalistic language-related fMRI task for this purpose. We examined the effectiveness of this task among 97 non-demented Chinese older adults from Hong Kong. The results showed that machine-learning classification models based on fMRI features extracted from the task and demographics (age, gender, and education year) achieved an average area under the curve of 0.86 when classifying participants' cognitive status (labeled as NORMAL vs DECLINE based on their scores on a standard neurcognitive test). Feature localization revealed that the fMRI features most frequently selected by the data-driven approach came primarily from brain regions associated with language processing, such as the superior temporal gyrus, middle temporal gyrus, and right cerebellum. The study demonstrated the potential of the naturalistic language-related fMRI task for early detection of aging-related cognitive decline and NCD.

The growing availability of longitudinal Magnetic Resonance Imaging (MRI) datasets has facilitated Artificial Intelligence (AI)-driven modeling of disease progression, making it possible to predict future medical scans for individual patients. However, despite significant advancements in AI, current methods continue to face challenges including achieving patient-specific individualization, ensuring spatiotemporal consistency, efficiently utilizing longitudinal data, and managing the substantial memory demands of 3D scans. To address these challenges, we propose Brain Latent Progression (BrLP), a novel spatiotemporal model designed to predict individual-level disease progression in 3D brain MRIs. The key contributions in BrLP are fourfold: (i) it operates in a small latent space, mitigating the computational challenges posed by high-dimensional imaging data; (ii) it explicitly integrates subject metadata to enhance the individualization of predictions; (iii) it incorporates prior knowledge of disease dynamics through an auxiliary model, facilitating the integration of longitudinal data; and (iv) it introduces the Latent Average Stabilization (LAS) algorithm, which (a) enforces spatiotemporal consistency in the predicted progression at inference time and (b) allows us to derive a measure of the uncertainty for the prediction. We train and evaluate BrLP on 11,730 T1-weighted (T1w) brain MRIs from 2,805 subjects and validate its generalizability on an external test set comprising 2,257 MRIs from 962 subjects. Our experiments compare BrLP-generated MRI scans with real follow-up MRIs, demonstrating state-of-the-art accuracy compared to existing methods. The code is publicly available at: https://github.com/LemuelPuglisi/BrLP.

The population is aging, and becoming more tech-savvy. The United Nations predicts that by 2050, one in six people in the world will be over age 65 (up from one in 11 in 2019), and this increases to one in four in Europe and Northern America. Meanwhile, the proportion of American adults over 65 who own a smartphone has risen 24 percentage points from 2013-2017, and the majority have Internet in their homes. Smart devices and smart home technology have profound potential to transform how people age, their ability to live independently in later years, and their interactions with their circle of care. Cognitive health is a key component to independence and well-being in old age, and smart homes present many opportunities to measure cognitive status in a continuous, unobtrusive manner. In this article, we focus on speech as a measurement instrument for cognitive health. Existing methods of cognitive assessment suffer from a number of limitations that could be addressed through smart home speech sensing technologies. We begin with a brief tutorial on measuring cognitive status from speech, including some pointers to useful open-source software toolboxes for the interested reader. We then present an overview of the preliminary results from pilot studies on active and passive smart home speech sensing for the measurement of cognitive health, and conclude with some recommendations and challenge statements for the next wave of work in this area, to help overcome both technical and ethical barriers to success.

Language-capable interactive robots participating in dialogues with human interlocutors must be able to naturally and efficiently communicate about the entities in their environment. A key aspect of such communication is the use of anaphoric language. The linguistic theory of the Givenness Hierarchy (GH) suggests that humans use anaphora based on the cognitive statuses their referents have in the minds of their interlocutors. In previous work, researchers presented GH-theoretic approaches to robot anaphora understanding. In this paper we describe how the GH might need to be used quite differently to facilitate robot anaphora generation.

For language-capable interactive robots to be effectively introduced into human society, they must be able to naturally and efficiently communicate about the objects, locations, and people found in human environments. An important aspect of natural language communication is the use of pronouns. Ac-cording to the linguistic theory of the Givenness Hierarchy(GH), humans use pronouns due to implicit assumptions about the cognitive statuses their referents have in the minds of their conversational partners. In previous work, Williams et al. presented the first computational implementation of the full GH for the purpose of robot language understanding, leveraging a set of rules informed by the GH literature. However, that approach was designed specifically for language understanding,oriented around GH-inspired memory structures used to assess what entities are candidate referents given a particular cognitive status. In contrast, language generation requires a model in which cognitive status can be assessed for a given entity. We present and compare two such models of cognitive status: a rule-based Finite State Machine model directly informed by the GH literature and a Cognitive Status Filter designed to more flexibly handle uncertainty. The models are demonstrated and evaluated using a silver-standard English subset of the OFAI Multimodal Task Description Corpus.

It captures and analyzes high-precision information about both outcome and process, opening up the possibility of detecting subtle cognitive impairment even when test results appear superficially normal. We describe the design and development of the test, document the role of AI in its capabilities, and report on its use over the past seven years. We outline its potential implications for earlier detection and treatment of neurological disorders. We set the work in the larger context of the THink project, which is exploring multiple approaches to determining cognitive status through the detection and analysis of subtle behaviors. Neurocognitive testing is the overall term for the efforts to assess the performance of our mental capabilities, including for example, memory, attention, problem solving, language and verbal fluency, cognitive processing speed, and others.

In the last years, knowledge technologies have been exploited for self-regulation functionalities inside e-learning systems. The definition of integrated system suitably scaffolding learners to improve their experi- ence is still lacking though. In this work, we propose an innovative Web-based educational environment that sustains metacognitive self-regulated learning processes upon Semantic Web and Social Web methods and technologies.

Multimodal conversational interfaces provide a natural means for users to communicate with computer systems through multiple modalities such as speech and gesture. To build effective multimodal interfaces, automated interpretation of user multimodal inputs is important. Inspired by the previous investigation on cognitive status in multimodal human machine interaction, we have developed a greedy algorithm for interpreting user referring expressions (i.e., multimodal reference resolution). This algorithm incorporates the cognitive principles of Conversational Implicature and Givenness Hierarchy and applies constraints from various sources (e.g., temporal, semantic, and contextual) to resolve references. Our empirical results have shown the advantage of this algorithm in efficiently resolving a variety of user references. Because of its simplicity and generality, this approach has the potential to improve the robustness of multimodal input interpretation.